| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| product name | Nifedipine |
| CAS NO. | 21829-25-4 |
| Specification | 99% |
| Appearance | yellow powder |
| Package | 1kg/Bag,25kg/Bag |
| MOQ | 1kg |
Nifedipine, also known as 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester, is a dihydropyridine calcium antagonist used to prevent and treat angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. It has no adverse effects on respiratory function, so it is suitable for patients with angina pectoris suffering from obstructive respiratory diseases, and its efficacy is better than that of beta receptor antagonists. It is also suitable for various types of hypertension, and has good efficacy for refractory and severe hypertension. Because it can reduce afterload, it also has good efficacy for refractory congestive heart failure and is suitable for long-term use.
| Items | Requirements | Results |
| Physical & Chemical | ||
| Appearance | yellow powder | Conform |
| Odor | Characteristic | Characteristic |
| Particle Size | 98% pass 80mesh | Complies |
| Loss on Drying | ≤5.0% | 3.65% |
| Ash | ≤5.0% | 1.96% |
| Solvent Residue | Meet USP standard | Complies |
| Pesticide Residue | Meet USP standard | Complies |
| Heavy Metal | ||
| Lead (Pb) | ≤2.0ppm | Conform |
| (As) | ≤1.0ppm | Conform |
| (Cd) | ≤1.0ppm | Conform |
| (Hg) | ≤0.1ppm | Conform |
| Microorganism | ||
| Total Plate Count | ≤1000cfu/g | Conform |
| Yeasts and Molds | ≤100cfu/g | Conform |
| Saimonella | Negative/25g | Conform |
| E.coli | Negative | Conform |
| Assay | 98% | 99.5% |
Nifedipine can be used to treat diseases such as hypertension and angina pectoris. In addition, nifedipine is currently used clinically to treat urinary tract stone colic, neurogenic urinary frequency in children, biliary colic and gastrointestinal spasm.
Functions and indications
1. Angina pectoris: variant angina pectoris; unstable angina pectoris; chronic stable angina pectoris.
2. Hypertension (alone or in combination with other antihypertensive drugs).
Usage and dosage
1. The dose of nifedipine should be gradually adjusted according to the patient's tolerance and control of angina pectoris. Overdose of nifedipine can cause hypotension.
2. Start with a small dose, generally starting at 10 mg/time, 3 times a day orally; the commonly used maintenance dose is 10-20 mg/time orally, 3 times a day. Some patients with obvious coronary spasm can use up to 20-30 mg/time, 3-4 times a day. The maximum dose should not exceed 120 mg/day. If the condition is urgent, 10 mg can be chewed or taken sublingually each time, and the dose can be re-administered based on the patient's response to the drug.
3. It usually takes 7 to 14 days to adjust the dose. If the patient has obvious symptoms and the condition is urgent, the dose adjustment period can be shortened. Depending on the patient's response to the drug, the frequency of attacks, and the dose of sublingual nitroglycerin, the dose of nifedipine can be adjusted from 10 to 20 mg to 30 mg/time, 3 times a day within 3 days.
4. For hospitalized patients under strict monitoring, the dose can be increased every 4 to 6 hours, 10 mg each time, depending on the control of angina pectoris or ischemic arrhythmias.
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