| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| product name | Amoxicillin |
| CAS NO. | 26787-78-0 |
| Specification | 99% |
| Appearance | white powder |
| Package | 1KG/Bag,25Kg/drum |
| MOQ | 1kg |
Amoxicillin is an organic compound with a chemical formula of C16H19N3O5S. It is an antibiotic drug, also known as amoxicillin, belonging to the aminopenicillin class of the penicillin family. It is a white or off-white crystalline powder with a slightly specific odor and bitter taste. It is the main variety of the second-generation penicillin. It is a broad-spectrum semi-synthetic antibiotic that can inhibit the synthesis of bacterial cell walls. It has a highly effective broad-spectrum antibacterial effect and very little toxic side effects. It is often used to treat bacterial infections such as middle ear infections, streptococcal pharyngitis, pneumonia, skin infections and urinary tract infections. The World Health Organization (WHO) recommends this product as the preferred β-lactam oral antibiotic, and it occupies an important position in oral antibiotics.
Melting point: 140 °C
Boiling point: 743.2 ± 60.0 (predicted)
Density: 1.6 ± 0.1 g/cm3
Flash point: 403.3 °C
Refractive index: 1.745 [1]
Water solubility: 4 g/L (25 °C)
Form: solid
Color: white powder
Since the side chain donor p-hydroxyphenylglycine cannot obtain a stable acyl chloride, the Danish anhydride method is currently used, which is also the main production method of amoxicillin side chain. p-hydroxyphenylglycine and methyl acetoacetate are prepared into p-hydroxyphenylglycine potassium salt, which is then mixed to prepare a mixed anhydride. The mixed anhydride and 6-PAP are then condensed, hydrolyzed, crystallized and other processes to obtain amoxicillin.
In addition to the traditional chemical synthesis method, there is also an enzyme synthesis method. Compared with chemical synthesis, the quality of amoxicillin prepared by enzymatic preparation is better than that of chemical synthesis due to mild process conditions and green environmental protection. Therefore, the enzymatic synthesis of amoxicillin has been increasingly studied and applied. p-hydroxyphenylglycine and 6-APA can be directly synthesized into amoxicillin under the catalysis of enzymes.
| Items | Standards | Results |
| Physical Analysis | ||
| Appearance | white powder | Complies |
| Specification | 99% | Complies |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Ash | ≤ 5.0% | 2.85% |
| Loss on Drying | ≤ 5.0% | 2.85% |
| Chemical Analysis | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | Complies |
| As | ≤ 1.0 mg/kg | Complies |
| Hg | ≤ 0.1 mg/kg | Complies |
| Microbiological Analysis | ||
| Total Plate Count | ≤ 1000cfu/g | Complies |
| Yeast&Mold | ≤ 100cfu/g | Complies |
| E.coil | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion: in conformity with the enterprise standard | ||
Amoxicillin is used to treat a variety of infections, including acute otitis media, streptococcal pharyngitis, pneumonia, skin infections, urinary tract infections, salmonella infections, Lyme disease, and chlamydia infections .
Acute otitis media
Children younger than six months of age are usually treated with amoxicillin or other antibiotics for acute otitis media. Although most children older than two years of age do not benefit from amoxicillin or other antibiotics, children younger than two years of age with bilateral acute otitis media or those with ear drainage may benefit from amoxicillin or other antibiotics .
Respiratory tract infections
Amoxicillin and amoxicillin-clavulanic acid can be used to treat bacterial sinusitis and other respiratory tract infections. Most sinus infections are caused by viruses, against which amoxicillin and amoxicillin-clavulanate are ineffective, and the small benefit of amoxicillin may be offset by its adverse effects . The National Institute for Health and Care Excellence recommends amoxicillin as the preferred first-line treatment for community-acquired pneumonia in adults, either alone (mild to moderate disease) or in combination with a macrolide. The World Health Organization (WHO) recommends amoxicillin as first-line treatment for non-"severe" pneumonia . Amoxicillin can be used for post-exposure inhalation therapy of anthrax to prevent exacerbations and for prophylaxis .
Helicobacter pylori
It is effective as part of a multidrug regimen for the treatment of H. pylori stomach infections. It is often used in combination with a proton pump inhibitor (such as omeprazole) and a macrolide antibiotic (such as clarithromycin) .
Lyme borreliosis
Amoxicillin is effective for the treatment of early cutaneous Lyme borreliosis and is no less effective and safe than commonly used alternative antibiotics when taken orally
Skin infections
Amoxicillin is occasionally used to treat skin infections such as acne vulgaris. Amoxicillin is often an effective treatment for cases of acne vulgaris that do not respond well to other antibiotics such as doxycycline and minocycline
Infant infections in resource-limited settings
The World Health Organization recommends that amoxicillin be used to treat infants with signs and symptoms of pneumonia in resource-limited settings when parents are unable or unwilling to hospitalize their child. Amoxicillin is recommended in combination with gentamicin for infants with other serious infections when hospitalization is not an option
Prevention of bacterial endocarditis
Amoxicillin is also used to prevent bacterial endocarditis and as an analgesic for people at high risk for dental procedures, to prevent pneumonia and other endocardial infections in people without spleens (such as those with sickle cell disease), and to prevent and treat anthrax .
Combination therapy
Amoxicillin is easily degraded by bacteria that produce beta-lactamases, which are resistant to most beta-lactam antibiotics (such as penicillins). Therefore, it can be used with the beta-lactamase inhibitor clavulanic acid. This combination is often called combined amoxicillin .
Range of activity
It is a moderately broad-spectrum, bactericidal beta-lactam antibiotic from the aminopenicillin family used to treat susceptible gram-positive and gram-negative bacteria. It is better absorbed after oral administration than other beta-lactam antibiotics and is therefore usually the first choice among this class of antibiotics. In general, Streptococci, Bacillus subtilis, Enterococci, Haemophilus, Helicobacter, and Moraxella are susceptible to amoxicillin, while Citrobacter rodentium, Klebsiella, and Pseudomonas aeruginosa are resistant to amoxicillin.
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