Nutritional Supplements Vitamin E Polyethylene Glycol Succinate Tpgs CAS 9002-96-4 Tocopherosolan

• Customization: Available
• CAS No.: 9002-96-4
• Formula: (C2h4o)Nc33h54o5
• Model NO.: SENTIAN-Vitamin E Polyethylene Glycol Succinate
• EINECS: /
• Type: Pharmaceutical Intermediates
• Appearance: White to Light Brown Waxy Solid
• Quality: Refined
• Colour: White
• Product Name: Vitamin E Polyethylene Glycol Succinate
• Test Method: HPLC
• Sample: 5-10g
• MOQ: 1kg
• Storage: Cool Dry Place
• Package: Drum, Vacuum Packed
• Express Time: 5-7 Days
• Shipping Method: by Express, Air or Sea, Provide The Most Cost-Effe
• Payment Method: Credit Card, T/T, Paypal, Western Union and Other
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 99%
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 500kg/Month

Product Description

Describtion

 

 

Vitamin E TPGS, is a water-soluble derivative of the natural form of d-α-tocopherol. In addition to serving as water-soluble source of vitamin E, TPGS has unique properties due to its dual combination of lipophilicity and hydrophilicity, similar to a surface-active agent. Its applications include formulation of lipophilic and poorly soluble nutrients and natural compounds and enhanced absorption and bioavailability. TPGS has a proven record of safety and efficacy in pharmaceuticals, food and beverage, personal care and cosmetics. It is particularly valued for its ability to enhance the bioavailability of poorly soluble drugs, improve drug solubility, and act as a solubilizer, emulsifier, and absorption enhancer. 

Acetaminophen SPECIFICATION
Product name	Vitamin E Polyethylene Glycol Succinate
CAS No.	9002-96-4
Specification	99%
Appearance	White to light brown waxy solid
Package	1KG/Bag,5kg/bag,25kg/drum
Place of Origin	Shaan'Xi,China

Application & Funtion

 

Function:

1. Solubility Enhancement
TPGS is often used to improve the solubility of poorly water-soluble drugs. This is crucial for increasing the bioavailability of these drugs. The mechanism involves the reduction of interfacial tension and the formation of micelles that encapsulate the hydrophobic drug molecules, enhancing their dissolution.

2. Emulsification
In formulations requiring stable emulsions, TPGS serves as an effective emulsifying agent. Its amphiphilic nature allows it to stabilize oil-in-water emulsions, which is particularly useful in topical formulations and certain oral and parenteral formulations.

3. Bioavailability Enhancement
TPGS has been shown to inhibit P-glycoprotein (P-gp), a drug efflux transporter that reduces the absorption of many drugs. By inhibiting P-gp, TPGS enhances the absorption and bioavailability of these drugs. This is particularly beneficial for drugs that are substrates of P-gp.

4. Controlled Release Formulations
In some controlled release formulations, TPGS is used to modulate the release profile of the active pharmaceutical ingredient (API). This can be achieved by incorporating TPGS into matrix systems or coatings that control the drug release rate.

5. Lipid-Based Drug Delivery Systems
TPGS is an integral component of lipid-based drug delivery systems, such as liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs). These systems can improve the stability, solubility, and bioavailability of encapsulated drugs.

6. Nanoparticle Formulations
TPGS is commonly used in the formulation of nanoparticles, which can be designed for targeted drug delivery. The incorporation of TPGS in these systems can improve the stability and efficacy of the nanoparticles.

Application:

TPGS is widely used in many fields:

Pharmaceuticals: TPGS is mainly used in the pharmaceutical industry to dissolve and formulate lipophilic and poorly soluble drugs to improve the absorption and bioavailability of drugs. It can also be used as a P-gp inhibitor to overcome the multidrug resistance (MDR) of various tumors.

Cosmetics and personal care: In personal care and cosmetics, TPGS is used as a formulation enhancer for water-soluble vitamin E and other active ingredients. It is hypoallergenic and non-irritating and is suitable for various skin care and care products.

Food and nutritional supplements: In the United States, TPGS can be used as a source of vitamin E in dietary supplements and foods. In Europe, it is also widely used in food additives.

 

 

Company

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.