| Customization: | Available |
|---|---|
| CAS No.: | 14605-22-2 |
| Formula: | C26h45no6s.2H2O |
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| CAS NO. | 14605-22-2 | |
| Specification | 99% | |
| Appearance | White powder | |
| packing | 25kg/drum | |
| MOQ | 25KG |
Tauroursodeoxycholic acid (TUDCA), whose chemical name is 3α, 7β-dihydroxycholanoyl-N-taurine, is a conjugated bile acid formed by the condensation between the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine.
| Item | Specification | Test result |
| Appearance | white powder | Conforms |
| Assay | 99% | Conforms |
| Heavy metal | ≤10ppm | Conforms |
| Lead | ≤2.0ppm | Conforms |
| As | ≤2.0ppm | Conforms |
| Ca | ≤1.0ppm | Conforms |
| Me | ≤0.1ppm | Conforms |
| Total aerobic microbial count | ≤1000CFU/g | Conforms |
| Total moulds&yeast count | ≤100CFU/g | Conforms |
| Enterobacterial | ≤10MPN/g | Conforms |
| Salmonella | N.D/25g | Conforms |
| Escherichia coli | N.D/10g | Conforms |
| Staphylococcus aureus | N.D/10g | Conforms |
| Pseudomonas aeruginosa | N.D/10g | Conforms |
| Conclusion: Conform with specification. | ||
Synthesis method
Tauroursodeoxycholic acid is an effective component of bear bile, and has significant therapeutic effects in treating gallstones and liver diseases. In recent years, the research field of tauroursodeoxycholic acid has been very active, and its chemical synthesis has also attracted much attention. In China, tauroursodeoxycholic acid is mainly obtained by artificially extracting bear bile, which has low purity and is not conducive to large-scale production. [2] Chemical synthesis of tauroursodeoxycholic acid. There are three main chemical semi-synthetic methods reported abroad:
1.Ursodeoxycholic acid (2) reactsor to form a mixed anhydride, which reacts with taurine (5) under alkaline conditions and is then purified by ion exchange column to obtain 1, with a total yield of about 62%;
2. 2 and 5 are directly condensed under alkaline conditions with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) or diethyl phosphorocyanidate (DEPC) to obtain 1, with yields of 67% and 90%, respectively. This method has expensive reagents;
3.2 and form a mixed anhydride, which is then condensed with p-hydroxypropiophenone to obtain the active phenolic ester of 2, which is then reacted with taurine to obtain 1, with a total yield of about 64%. This method has many reaction steps. Comparing the three synthesis methods, the latter two require EEDQ and DEPC, which are expensive and complicated to prepare. Therefore, it is unlikely that there will be effective reagents and methods to replace bear bile in the short term.
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