Isosorbide Dinitrate Powder 99% CAS 87-33-2

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: ST-Isosorbide dinitrate
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Product Name: Isosorbide Dinitrate
• Test Method: HPLC
• Storage: Cool Dry Place
• MOQ: 1 Kg
• Sample: 5-10g Free Sample
• Appli: Health Care Products, Medicine
• Shelf Life: 2 Years
• Transport: 1kg/Alu-Foil Bag, 25kg/Drum
• Sta: Powder
• Gra: Grade
• Free Sample: 10g~20g
• Ori: Shaanxi China
• Production: 5000 Kgs Per Month
• Health: Yes
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 99%
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 50000 Tons/Year

Product Description

 

Product Name:Isosorbide dinitrate
Synonyms:1,4:3,6-dianhydro-,dinitrate,d-glucito;1,4:3,6-dianhydro-d-glucitodinitrate;1,4:3,6-dianhydrosorbitol2,5-dinitrate;cardis;carvanil;carvasin;[(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate;Isosorbitol dinitrate
CAS:87-33-2
MF:C6H8N2O8
MW:236.14
EINECS:201-740-9
Purity:99%
Shelf life:2 years
Storage:Keep in cool dry place.
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.

 

 

Function

 

 

Function

Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxid e (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Application

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.