Affordable Premium Health Food: Benfotiamine for Better Living

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: Sentian-benfotiamine
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Address: Shaan′xi, China
• Single Gross Weight: 1.500kg
• Instruction for Use: Powder
• Selling Units: Single Item
• Sample: 10-20g
• Ingredients: Vitamin B Complex
• Single Package Size: 23X33X5cm
• Appearance: Yellow Powder
• Storage: Cool Dry Place
• Package: 1kg/Bag 25kg/Drum
• Athar Nlamoe: Witamin H Comnlov
• Application: Feed Addictive
• Active Ingredient: Benfotiamine
• Sto: Cool Dry Place
• Level: Food Grade
• Transport Package: Aluminium Bag Outside and Double Plastic Bag Insid
• Specification: 99%Purity
• Trademark: Sentian
• Origin: Shaan′xi, China
• Production Capacity: 50000

Product Description

Description

• Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions".

  Benfotiamine CAS 22457-89-2 is a fat-soluble derivative of vitamin B1, which improves the shortcomings of low bioavailability of water-soluble vitamin B1, increases the concentration of thiamine in blood and tissues, and improves the effect.
•  

  Name	Benfotiamine
  CAS NO	22457-89-2
  Molecular formula	C19H23N4O6PS
  Molecular Weight	466.448
  Density	1.4±0.1 g/cm3
  Boiling point	745.1±70.0 °C at 760 mmHg
  Melting point	165ºC
  Flash point	404.4±35.7 °C
  PSA	191.05000
  LogP	1.81
  Package	Drum / Aluminum Foil Bag / According to customer's requiement

Application & Funtion

1. Diabetic neuropathy
Benfotiamine treatment appears to be a potential strategy for preventing diabetic nephropathy, a serious complication of diabetes that is associated with a higher risk of heart disease and mortality. High glucose concentrations lead to the accumulation of triose phosphate; this leads to biochemical dysfunction and eventual development of diabetic nephropathy.
Preclinical studies in rats show that benfotiamine prevents the accumulation of triose phosphate in diabetes, thereby inhibiting the development of kidney disease.

2. Cognitive improvement in Alzheimer's disease
Preclinical studies suggest that benfotiamine has beneficial effects on cognitive impairment in Alzheimer's disease. Benfotiamine has been shown to reduce amyloid deposits in animal models of Alzheimer's disease. However, these effects have not been demonstrated in humans. A phase II clinical trial is currently evaluating whether benfotiamine can prevent cognitive decline in people with mild cognitive impairment.

3. Overcome alcohol dependence
Chronic alcohol intake is associated with severe deficiencies of important nutrients and vitamins. Alcoholism-related thiamine deficiency is characterized by a neurological syndrome due to progressive loss of central and peripheral white matter. Although thiamine replacement is important in patients with alcohol-induced CNS injury, benfotiamine has not been shown to be effective in peripherally entering the CNS.

4. Benfotiamine for smoking
Smoking causes endothelial dysfunction, an early event in cardiovascular disease. Oxidative stress and inflammation can exacerbate this. In preclinical studies in rats, benfotiamine was found to prevent nicotine-induced vascular dysfunction. A trial in healthy volunteers showed that short-term treatment with benfotiamine partially restored macrovascular function in healthy smokers.

5. Kidney Protection
Data from rat studies suggest that benfotiamine has a protective effect on the peritoneum and residual kidney during peritoneal dialysis and uremia. According to a study published in the Journal of the American Academy of Nephrology, adding benfotiamine to the diet resulted in increased transketolase activity and decreased expression of advanced glycation end products and their receptors.

A study by Ustuner et al. Research published in Tissue and Cell found that benfotiamine supplementation may help reduce antibiotic-induced nephrotoxicity by improving oxidative stress and inflammation in renal tubular cells.

6. Anti-tumor potential
In vitro studies suggest that benfotiamine may block leukemia through a mechanism called apoptosis. Paposis is a type of programmed cell death involving the formation of cytoplasmic vacuoles. A cell culture study by researchers at Kanazawa University in Japan found that benfotiamine is a promising drug for patients with acute myeloid leukemia who are not eligible for standard chemotherapy. They also observed that benfotiamine worked synergistically with the chemotherapy drug cytarabine to eliminate myeloid leukemia cells.

7. Antioxidant properties
Benfotiamine is also a potent antioxidant with anti-inflammatory properties by inhibiting the synthesis of prostaglandins and leukotrienes.

 

 

COA

Items	Requirements	Results
Physical & Chemical
Appearance	white powder	Conform
Odor	Characteristic	Characteristic
Particle Size	98% pass 80mesh	Complies
Loss on Drying	≤5.0%	3.65%
Ash	≤5.0%	1.96%
Solvent Residue	Meet USP standard	Complies
Pesticide Residue	Meet USP standard	Complies
Heavy Metal
Lead (Pb)	≤2.0ppm	Conform
(As)	≤1.0ppm	Conform
(Cd)	≤1.0ppm	Conform
(Hg)	≤0.1ppm	Conform
Microorganism
Total Plate Count	≤1000cfu/g	Conform
Yeasts and Molds	≤100cfu/g	Conform
Saimonella	Negative/25g	Conform
E.coli	Negative	Conform
Assay	98%	98.5%

Company Profile

Xi'an sentian Biological is located in the world-famous ancient city - Xi'an, China. We mainly provide the export of health product raw materials for the world, mainly plant extracts, vitamins, amino acids, natural pigments, cosmetic raw materials, loss weight series, probiotics, and we also provide OEM services.In the process of company development, we also constantly improve our product system in order to bring more choices to customers.
We have an experienced team and currently cooperate with customers in more than 30 countries, with Europe and North America as the main markets, including world-renowned companies.
At present, it has passed ISO certification, and will also complete kosher, halal, organic certificates in the future.
In order to provide better products and services, our company has a professional training system and a perfect work flow.
We always put the interests of our customers first and aim to improve customer value.
Adhering to the business principle of mutual benefits, we have had a reliable reputation among our customers because of our professional services, quality products and competitive prices. We warmly welcome customers from at home and abroad to cooperate
with us for common success.

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