| product name |
Coenzyme Q10 |
| Specification |
10% |
| OEM/ODM |
yes |
| Package |
1KG/Bag,5kg/bag,25kg/drum |
| Appearance |
Orange powder |
| MOQ |
1KG |
Coenzyme Q10 (Coenzyme Q10, CoQ10), also known as Ubiquinone (UQ) and Coenzyme Q (CoQ), is a coenzyme present in all eukaryotic organisms that perform aerobic respiration. Q represents the quinone group, and 10 represents the number of isoprene attached to its tail. It is mainly formed in the inner membrane of mitochondria, and a small part can also be obtained through food, such as beef, eggs, oily fish, nuts, oranges, broccoli and other fruits and vegetables.
Coenzyme Q10 is widely distributed in the human body and exists in various organs, tissues, subcellular components and plasma, but its content varies greatly. The mass concentration is higher in tissues and organs such as the liver, heart, kidneys and pancreas. The main function is to drive human cells to produce energy. Coenzyme Q10 is mainly involved in the mitochondrial oxidative phosphorylation and ATP production process, regulates the cell redox environment, carries reduced electrons into the vesicle or out of the cell during the electron membrane penetration process, and participates in the formation of the proton gradient of the inner membrane and plasma membrane. It can accelerate cell renewal and stimulate cell activity, thereby greatly promoting the ability of cells to absorb nutrients. Adding coenzyme Q10 ingredients to skin care products can effectively help skin cells actively absorb other nutrients in skin care products, and has health-preserving effects such as accelerating metabolism and slowing down aging.
As a health product, coenzyme Q10 has the functions of protecting the heart, enhancing energy, and improving immunity. It is suitable for athletes, high-intensity mental workers, and the stabilization and recovery of patients with heart disease, diabetes, etc.
In China, there are two types of coenzyme Q10: medicinal and health products. Coenzyme Q10 is often used clinically as an adjuvant treatment for cardiovascular diseases, such as viral myocarditis, heart failure, and congestive heart failure. The main effect of coenzyme Q10 on the myocardium is to promote cellular oxidative phosphorylation, which has a certain protective effect on ischemic myocardium; increase cardiac blood output, which is beneficial for the treatment of heart failure; improve chronic congestive state and anti-arrhythmia, and provide sufficient energy for the myocardium. In addition, the approved indications of coenzyme Q10 in China include: adjuvant treatment of hepatitis; reduction of some adverse reactions caused by cancer radiotherapy and chemotherapy, etc. In addition, some health products promote the effects of lowering blood pressure, lowering blood lipids, and anti-aging, but there is no definite evidence that regular supplementation of coenzyme Q10 can bring benefits. It should be noted that although coenzyme Q10 is an approved drug for marketing in China, it does not mean that it is a first-line drug for the treatment of diseases. The instructions for the drug also clearly state that it is only used for adjuvant treatment. The U.S. FDA (Deal Administration) has never approved coenzyme Q10 as a drug, but only marketed it as a food supplement, which means it is a health product.
| Items |
Standards |
Results |
| Physical Analysis |
| Appearance |
Orange powder |
Complies |
| Specification |
10% |
Complies |
| Mesh Size |
100 % pass 80 mesh |
Complies |
| Ash |
≤ 5.0% |
2.85% |
| Loss on Drying |
≤ 5.0% |
2.85% |
| Chemical Analysis |
| Heavy Metal |
≤ 10.0 mg/kg |
Complies |
| Pb |
≤ 2.0 mg/kg |
Complies |
| As |
≤ 1.0 mg/kg |
Complies |
| Hg |
≤ 0.1 mg/kg |
Complies |
| Microbiological Analysis |
| Total Plate Count |
≤ 1000cfu/g |
Complies |
| Yeast&Mold |
≤ 100cfu/g |
Complies |
| E.coil |
Negative |
Negative |
| Salmonella |
Negative |
Negative |
| Conclusion: in conformity with the enterprise standard |
Anti-wrinkle and anti-aging
Local experiments have shown that with age, the ability of skin collagen to resist damage from oxidative stimuli such as ultraviolet rays decreases. Long-term use of coenzyme Q10 can effectively prevent skin photoaging and reduce wrinkles around the eyes, because coenzyme Q10 penetrates into the skin growth layer and can It weakens the oxidative reaction of photons and, with the assistance of tocopherol, can activate specific phosphorylated tyrosine kinases to prevent oxidative damage to DNA, inhibit the expression of collagenase in human skin fibroblasts under ultraviolet light, and protect the skin from damage. Extensive research suggests that coenzyme Q10 inhibits lipid peroxidation, reduces the generation of free radicals, protects the SOD active center and its structure from free radical oxidative damage, increases the activity of SOD and other enzymes in the body, and inhibits cell apoptosis induced by oxidative stress. , has significant antioxidant and anti-aging effects.
Anti-fatigue
In the mid-1970s, Mitchell's chemiosmotic hypothesis revealed the energy conversion in organisms and the important role of coenzyme Q10 in the mitochondrial energy conversion system.
Coenzyme Q10 is a coenzyme of at least three mitochondrial enzymes (multienzyme complex I, II and III). Its chemical structure is a 2,3-dimethoxy group with an isoprene side chain attached to the 6th carbon. . Its quinone ring plays the role of transferring electrons and protons in the oxidative respiratory chain. This role is the key to the formation of ATP and is essential for all life forms. ATP is the main form of energy storage for the body and an important basis for the normal functioning of all cells. The biological activity of coenzyme Q10 mainly comes from the redox properties of its quinone ring and the physical and chemical properties of its side chain. It is a natural antioxidant and cell metabolism initiator produced by the cells themselves. It has the functions of protecting and restoring the integrity of the biological membrane structure and stabilizing the membrane potential. It is a non-specific immune enhancer of the body, so it shows excellent anti-fatigue effect. Q10 keeps cells in a good and healthy state, so the body is full of vitality, energy and brain power.
Muscle Energy
Experiments have shown that Coenzyme Q10 can greatly promote heart health, and appropriate levels of Coenzyme Q10 in the human body are necessary for proper muscle function. Biochemical analysis of muscle cell extracts found that when the concentration of coenzyme Q10 was 20% lower than normal, the functional activity of the cell mitochondrial complex I+II and complex I+III was severely reduced. Several studies have clearly shown that supplementation with 100-150 mg/day of CoQ10 can significantly improve the condition of people suffering from muscular dystrophy. Many overweight people have very low levels of Coenzyme Q10, and supplementation can help them lose weight. This is because Coenzyme Q10 can accelerate the metabolism of fat, provide ample energy supply to the limbs and brain, and make people energetic.
Anti-tumor and immunomodulatory effects
Recent studies have shown that coenzyme Q10 has anti-tumor effects and has a certain clinical effect on advanced metastatic cancer. It can also prevent coronary heart disease, relieve periodontitis, treat duodenal ulcers and gastric ulcers, enhance human immunity and relieve It has significant effect on angina pectoris.
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