| Customization: | Available |
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| Powder: | Yes |
| Customized: | Non-Customized |
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Itraconazole is a triazole antifungal agent that is widely used for the prevention and treatment of various fungal infections. It is particularly effective against a broad spectrum of fungi, including Aspergillus and Candida species, as well as Blastomyces dermatitidis and Histoplasma capsulatum. The drug is available under brand names such as Sporanox and Tolsura, and it comes in both capsule and oral solution forms.
The primary mechanism of action of itraconazole involves the inhibition of the cytochrome P450 enzyme, specifically the 14α-demethylase, which is essential for the synthesis of ergosterol in fungal cell membranes. By blocking this enzyme, itraconazole prevents the conversion of lanosterol to ergosterol, leading to an accumulation of 14-methylated sterols. This results in increased cell membrane permeability, altered membrane-bound enzyme activity, and disrupted chitin synthesis, ultimately leading to the death of the fungal cell.
Itraconazole is indicated for the treatment of conditions such as aspergillosis, blastomycosis, histoplasmosis, and onychomycosis. It is also used for oropharyngeal and esophageal candidiasis. The drug is well-absorbed after oral administration, with peak plasma concentrations typically reached within two to five hours. Its absorption is maximized under adequate gastric acidity, and it exhibits non-linear pharmacokinetics, leading to accumulation in plasma during multiple dosing.
| Product Information | |
| Other Name | Itraconazole |
| Assay | 99% |
| Appearance | White crystalline powder |
| Package | 1kg/carton; 25kg/drum |
| Payment | Alipay; Western Union; TT |
| Shipment | DHL; FedEx, EMS; Air; Sea |
| Standard | USP/EP/CP/BP |
| Storage | Sealed in dark and dry place |
| Shelf Life | 3 Years |
Antifungal Treatment: Itraconazole is primarily used for the treatment of various fungal infections, including but not limited to systemic mycoses, dermatomycoses, and onychomycosis.
Immunocompromised Patients: It is prescribed for immunocompromised individuals, such as those with HIV/AIDS or undergoing chemotherapy, who are more susceptible to fungal infections.
Preventive Therapy: Itraconazole can also be employed as a prophylactic agent to prevent fungal infections in high-risk individuals or in settings where exposure to fungi is anticipated.
Inhibition of Fungal Cell Membrane Synthesis: By inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, itraconazole disrupts membrane integrity and function, leading to fungal cell death.
Broad-Spectrum Activity: Its mechanism of action enables itraconazole to exhibit broad-spectrum antifungal activity against a wide range of fungal species, including yeasts, molds, and dermatophytes.
Oral Bioavailability: Administered orally, itraconazole achieves good bioavailability, allowing it to reach therapeutic concentrations in the bloodstream and distribute throughout the body, making it effective against systemic and deep-seated fungal infections.
Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.
Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short
Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.
Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.
Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.
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