TPGS stands for Tocopheryl Polyethylene Glycol 1000 Succinate. It is a water-soluble, nonionic vitamin E derivative. TPGS is derived from natural vitamin E and modified to improve its solubility in aqueous systems. It is commonly available in the form of yellow to light brown powder.
TPGS has several important functions in various industries. Firstly, it acts as a solubilizer and emulsifier, helping to enhance the solubility and stability of poorly water-soluble drugs and nutraceuticals in aqueous environments. Secondly, TPGS exhibits excellent antioxidant properties, which can protect sensitive compounds from oxidation and degradation. Additionally, TPGS has been found to enhance drug absorption through various mechanisms, including inhibition of efflux transporters and improvement of mucosal permeability.
Medicinal Field:
It is mainly used as excipient and absorption enhancer. Due to its emulsifying and solubilizing effects, it can effectively improve the bioavailability of drugs. Thus, it can reduce the amount of drug use and reduce the toxic side effects of drugs.
1. Anti-tumor drug: FDA approved paclitaxel emulsion formulation (Sonus Pharmaceuticals)
2. Anti-HIV drugs: Agenerase (Amprenavir) and APTIVUS (Telanavir).
3. Anti-hepatitis C virus (HCV) drugs: VIEKERA Pack tablets.
4. Ophthalmic medications: dry eye; prevention of contact lens wear; healing of the postoperative cornea.
5. Treatment of vitamin E deficiency caused by chronic bile deficiency.
Food and Cosmetics Field:
1. Converts a wide range of natural nutrients into stable, water-soluble liquids or powders.
2. Has antioxidant and anti-aging effects.
| Items |
Requirements |
Results |
| |
|
|
| Physical & Chemical |
|
|
| Appearance |
White powder |
Conform |
| Odor |
Characteristic |
Characteristic |
| Particle Size |
98% pass 80mesh |
Complies |
| Loss on Drying |
≤5.0% |
3.65% |
| Ash |
≤5.0% |
1.96% |
| Solvent Residue |
Meet USP standard |
Complies |
| Pesticide Residue |
Meet USP standard |
Complies |
| |
|
|
| Heavy Metal |
|
|
| Lead (Pb) |
≤2.0ppm |
Conform |
| (As) |
≤1.0ppm |
Conform |
| (Cd) |
≤1.0ppm |
Conform |
| (Hg) |
≤0.1ppm |
Conform |
| |
|
|
| Microorganism |
|
|
| Total Plate Count |
≤1000cfu/g |
Conform |
| Yeasts and Molds |
≤100cfu/g |
Conform |
| Saimonella |
Negative/25g |
Conform |
| E.coli |
Negative |
Conform |
| |
|
|
| |
|
|
| Assay |
98% |
98.5% |
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