| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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| product name | Fudosteine |
| CAS NO. | 13189-98-5 |
| Specification | 99% |
| Appearance | white powder |
| Package | 1KG/Bag,25kg/drum |
| MOQ | 1KG |
Fudosteine, chemically known as (-)-(R)-2-amino-3-(3-hydroxypropylthio), is a type of cysteine derivative with a basic skeleton of steine developed by Mitsubishi Pharma Corporation and S.S. Pharmaceutical Co., Ltd. of Japan. It has multiple pharmacological effects on chronic respiratory diseases: inhibiting the proliferation of respiratory epithelial cells, normalizing the ratio of trehalose/sialic acid in sputum, restoring the state of ciliary transport of airway secretions, and having anti-inflammatory effects; it has the advantages of strong efficacy, small side effects, wide indications, and great market potential. It is suitable for expectoration of chronic respiratory diseases such as bronchial asthma, chronic bronchitis, bronchiectasis, tuberculosis, pneumoconiosis, emphysema, atypical mycobacterial infection, and diffuse bronchiolitis.
Appearance and properties: Off-white crystals
Density: 1.301 g/cm3
Melting point: 210.9-212.5ºC
Boiling point: 354.5ºC at 760 mmHg
Flash point: 168.2ºC
Refractive index: 1.558
Vapor pressure: 1.92E-06mmHg at 25°C [2]
Specific rotation: -19.0 - -23.0°
Chemical identification: Should show a positive reaction Infrared chromatography
The infrared absorption spectrum of this product should be consistent with that of the reference substance
Loss on drying ≤0.5%
Residue on ignition ≤0.5%
PH value 4.0---6.5
Total impurities ≤1.0%
Clarity of solution: The solution should be clear. If turbid, it should not be more concentrated than the No. 1 turbidity standard solution.
Chloride ≤ 0.05% Sulfate ≤ 0.05% Dextrofudosteine ≤ 0.5% Content determination ≥ 98.5% (based on dry product, including C6H13NO3S)
| Items | Standards | Results |
| Physical Analysis | ||
| Description | white powder | Complies |
| Specification | 99% | 99.20% |
| Mesh Size | 100 % pass 80 mesh | Complies |
| Loss on Drying | ≤ 5.0% | 0.03% |
| Chemical Analysis | ||
| Heavy Metal | ≤ 10.0 mg/kg | Complies |
| Pb | ≤ 2.0 mg/kg | Complies |
| As | ≤ 1.0 mg/kg | Complies |
| Hg | ≤ 0.1 mg/kg | Complies |
| Microbiological Analysis | ||
| Total Plate Count | ≤ 1000cfu/g | Complies |
| Yeast&Mold | ≤ 100cfu/g | Complies |
| E.coil | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion: in conformity with the enterprise standard | ||
Product use: used to treat chronic respiratory diseases such as bronchial asthma, bronchiectasis, chronic bronchitis, tuberculosis, pneumoconiosis, emphysema, etc.
Fudosteine is a mucolytic agent that can inhibit the excessive formation of goblet cells that secrete mucous sputum in the trachea and the production of high-viscosity fucoxomucin, reduce sputum viscosity, increase serous tracheal secretion, and inhibit tracheal inflammation.
Main diseases treated
Fudosteine is suitable for expectorant treatment of respiratory diseases such as bronchial asthma, chronic asthmatic bronchitis, bronchiectasis, tuberculosis, pneumoconiosis, chronic obstructive pulmonary emphysema, atypical mycobacterial disease, pneumonia, diffuse bronchitis, etc.
Applicable symptoms
Fudosteine is suitable for situations where sputum is thick and difficult to cough up.
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