Pharmaceutical Intermediate CAS 88150-42-9 99% Amlodipine Powder

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: ST-amlodipine
• Certification: ISO 9001, FDA
• Suitable for: Adult
• State: White Powder
• Purity: >99%
• OEM/ODM: Yes
• MOQ: 100g
• Sample: 5-10g
• Shelf Life: 2 Years
• Chemical Formula: Amlodipine
• Model No.: 99 Amlodipine
• Mf: C20h25cln2o5
• Einecs: 1308068-626-2
• Transport: 25kg/Drum, 1kg/Bag or According to Customer Reques
• MW: 408.88
• Melting Point: 178-179 C
• PUR: 99
• Transport Package: 10g/ Bag, 20g/Bag
• Specification: 99%
• Trademark: SENTIAN
• Origin: China
• Production Capacity: 500kg Per Month

Product Description

 

Description

Product name	Amlodipine
Cas No.	88150-42-9
Molecular Formula	C20H25ClN2O5
Appearance	Yellow crystalline powder

Amlodipine is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

COA

Items	Requirements	Results
Physical & Chemical
Appearance	White powder	Conform
Odor	Characteristic	Characteristic
Particle Size	98% pass 80mesh	Complies
Loss on Drying	≤5.0%	3.65%
Ash	≤5.0%	1.96%
Solvent Residue	Meet USP standard	Complies
Pesticide Residue	Meet USP standard	Complies
Heavy Metal
Lead (Pb)	≤2.0ppm	Conform
(As)	≤1.0ppm	Conform
(Cd)	≤1.0ppm	Conform
(Hg)	≤0.1ppm	Conform
Microorganism
Total Plate Count	≤1000cfu/g	Conform
Yeasts and Molds	≤100cfu/g	Conform
Saimonella	Negative/25g	Conform
E.coli	Negative	Conform
Assay	98%	98.5%

Application & Funtion

1.Amlodipine is indicated for the treatment of chronic stable angina; it may be used alone or in combination with other antianginal agents.
2.Amlodipine is indicated for the treatment of confirmed or suspected vasospastic angina. It may be used alone or in combination with other antianginal agents. 
3.Amlodipine is indicated for the treatment of hypertension; it may be used alone or in combination with other antihypertensive agents. 
4.Amlodipine is used in the treatment of hypertension, chronic stable angina pectoris, and vasospastic angina.
 

 

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