Salvianolic acid B is an organic compound with a molecular formula of C36H30O16 and a relative molecular mass of 718.62. It is a brown-yellow dry powder, and the pure product is an off-white powder or a light yellow powder; it tastes slightly bitter and astringent, and is hygroscopic. It is soluble in water.
Salvianolic acid B SPECIFICATION |
Product name
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Salvianolic acid B
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From
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Powder
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CAS No.
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115939-25-8
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Specification
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99%
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Appearance
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brown powder
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Package
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1KG/Bag,5kg/bag,25kg/drum
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Place of Origin
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Shaan'Xi,China
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Salvianolic acid B is formed by the condensation of three molecules of danshensu and one molecule of caffeic acid. It is one of the most studied salvianolic acids and has important pharmacological effects on organs such as the heart, brain, liver, and kidney. This product has the effects of promoting blood circulation and removing blood stasis, promoting blood circulation and activating collaterals. It is mainly used to treat ischemic stroke caused by blood stasis blocking the meridians. Symptoms include numbness of one half of the body, weakness, cramps and pain, or apraxia, crooked mouth and eyes, etc.
Antioxidant
Salvianolic acid B has a strong antioxidant effect. In vitro and in vivo experiments have shown that salvianolic acid B can scavenge oxygen free radicals and inhibit lipid peroxidation. Its effect is stronger than vitamin C, vitamin E, and mannitol. It is one of the strongest known natural products with antioxidant effects. Pharmacological studies have shown that salvianolic acid for injection has a significant antioxidant effect, inhibits platelet aggregation, inhibits thrombosis, and can prolong the survival time of animals under hypoxic conditions. The experiment showed that injection of salvianolic acid (60-15mg/kg) can significantly improve the neurological deficits of rats with cerebral ischemia-reperfusion injury, which is manifested as improved behavioral disorders and significantly reduced cerebral infarction area. There are statistical differences between high and medium doses (60 and 30mg/kg); injection of salvianolic acid significantly improved the neurological damage caused by cerebral ischemia in rats caused by FeCl3 at 1, 2, and 24 hours after administration, which is manifested as improved behavioral disorders and reduced cerebral infarction area; injection of salvianolic acid 40mg/kg significantly inhibited the aggregation reaction of rabbit platelets induced by ADP, arachidonic acid, and collagen, with inhibition rates of 81.5%, 76.7%, and 68.9%, respectively. Injection of salvianolic acid 60 and 30mg/kg significantly inhibited the formation of thrombus in rats; injection of salvianolic acid 60 and 30mg/kg significantly prolonged the survival time of mice under hypoxic conditions.
Protect the heart
Reperfusion of normal blood after acute myocardial ischemia can lead to further damage to the ischemic myocardium, which is manifested by severe cell damage, refractory arrhythmias and obvious cardiac dysfunction in the early stage after reperfusion, which is acute myocardial ischemia-reperfusion injury. During myocardial ischemia-reperfusion, a large number of free radicals are generated, cell membrane lipid peroxidation is enhanced, membrane fluidity and permeability change, leading to abnormal electrophysiological activity, inducing and promoting the occurrence of arrhythmias; myocardial cell lipid peroxidation is enhanced, resulting in an increase in the content of peroxidation product malondialdehyde (MDA) in the myocardial ischemic area, an increase in lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) in the coronary outflow fluid, and a decrease in superoxide dismutase (SOD) in myocardial tissue. Animal experimental studies have shown that salvianolic acid B can reduce the degree of myocardial ischemia in ischemia-reperfusion injury model animals, reduce the scope of myocardial infarction, reduce the overflow of LDH and CPK from the cell body, reduce the content of MDA in ischemic myocardial tissue, increase the activity of SOD, resist the toxic effects of oxygen free radicals on myocardial cells, and protect myocardial cells.





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