| Customization: | Available |
|---|---|
| CAS No.: | 9067-32-7 |
| Formula: | (C14h20no11na)N |
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| product name | Sodium Hyaluronate |
| CAS NO. | 9067-32-7 |
| Specification | 99% |
| Appearance | White powder |
| packing | 25kg/drum |
| MOQ | 25KG |
Sodium Hyaluronate is the sodium salt form of hyaluronic acid, also known as sodium hyaluronate, with a chemical formula of (C14H20NO11Na)n. It is a glucuronic acid and a natural polysaccharide that is widely found in human connective tissue, skin, eyes and joint fluid. It has excellent moisturizing, anti-aging, repair and lubricating functions [1], so it is widely used in beauty, medicine and health care. The molecular structure of sodium hyaluronate is formed by alternating arrangement of glucuronic acid and N-acetylglucosamine. It has a strong water absorption capacity. Each molecule can absorb hundreds of times its own weight of water, thus having a significant effect in maintaining skin hydration and improving skin elasticity. [2]
In beauty and skin care, sodium hyaluronate is often used in moisturizing products such as creams, essences, masks, etc. to help relieve dryness, tightness and fine lines, and keep the skin smooth and hydrated. In addition, sodium hyaluronate is also widely used in joint treatment (such as arthritis injections), ophthalmology (such as artificial tears) and wound repair to help relieve joint pain, accelerate wound healing and relieve dry eyes. Due to its high safety and naturalness, sodium hyaluronate has become an indispensable ingredient in modern medicine and skin care products.
| Item | Specification | Test result |
| Appearance | white powder | Conforms |
| Assay | 98% | Conforms |
| Heavy metal | ≤10ppm | Conforms |
| Lead | ≤2.0ppm | Conforms |
| As | ≤2.0ppm | Conforms |
| Ca | ≤1.0ppm | Conforms |
| Me | ≤0.1ppm | Conforms |
| Total aerobic microbial count | ≤1000CFU/g | Conforms |
| Total moulds&yeast count | ≤100CFU/g | Conforms |
| Enterobacterial | ≤10MPN/g | Conforms |
| Salmonella | N.D/25g | Conforms |
| Escherichia coli | N.D/10g | Conforms |
| Staphylococcus aureus | N.D/10g | Conforms |
| Pseudomonas aeruginosa | N.D/10g | Conforms |
| Conclusion: Conform with specification. | ||
Improve drug efficacy
Hyaluronic Acid is the main component of connective tissues such as the intercellular matrix, vitreous body, and synovial fluid of the human body. It has the characteristics of retaining water, maintaining extracellular space, regulating osmotic pressure, lubricating, and promoting cell repair in the body. As a carrier of ophthalmic drugs, it prolongs the retention time of drugs on the surface of the eye by increasing the viscosity of eye drops, improves the bioavailability of drugs, and reduces the irritation of drugs to the eyes.
Auxiliary therapeutic effect: It can be directly injected into the joint cavity as a lubricant for the treatment of arthritis. Moisturizing Sodium hyaluronate's moisturizing effect in skin tissue is one of its most important physiological functions. Adequate moisture makes the skin smooth and delicate. HA has the highest moisture absorption at low relative humidity (33%) and the lowest moisture absorption at high relative humidity (75%). It is suitable for the skin's moisturizing needs for cosmetics in different seasons and different environmental humidity, and there is no greasy feeling or feeling of blocked pores.
Anti-wrinkle property
The moisture level of the skin is closely related to the hyaluronic acid content. With the increase of age, the hyaluronic acid content in the skin decreases, which weakens the skin's water retention function and produces wrinkles. Sodium hyaluronate aqueous solution has strong viscoelasticity and lubricity. When applied to the skin surface, it can form a moisturizing and breathable film to keep the skin moisturized and shiny. Small molecule hyaluronic acid can penetrate into the dermis, promote blood microcirculation, and facilitate the skin's absorption of nutrients, playing a health care role in beauty and anti-wrinkle.
Sodium hyaluronate is a high molecular polymer. It has obvious lubrication and good hand feel when applied. The large molecules form a breathable film on the skin surface, making the skin smooth and moisturized, blocking the invasion of foreign bacteria, dust, etc. Small molecule sodium hyaluronate can penetrate into the dermis, which has the effect of slightly dilating capillaries, increasing blood circulation, improving intermediate metabolism, and promoting skin nutrient absorption, achieving the effect of lubrication and plumpness.
Sun protection and skin damage repair effect On the skin surface, it can eliminate the active oxygen free radicals generated by ultraviolet rays in the sun, protect the skin from ultraviolet damage, and promote skin regeneration in the injured area by promoting the proliferation and differentiation of epidermal cells.
Moisturizing effect
Sodium hyaluronate has a higher moisture absorption at low relative humidity and a lower moisture absorption at high relative humidity. This unique property is adapted to the skin's requirements for cosmetic moisturizing in different seasons and different environmental humidity, such as dry winter and humid summer. The moisturizing property of sodium hyaluronate is related to its quality. The higher the quality, the better the moisturizing property. Sodium hyaluronate is rarely used alone as a moisturizer, and is often used in combination with other moisturizers.
Nutritional effect
Sodium hyaluronate is a biological substance inherent in the skin. Exogenous sodium hyaluronate is a supplement to endogenous sodium hyaluronate in the skin. Sodium hyaluronate with a smaller mass can penetrate into the epidermis of the skin, promote the supply of skin nutrition and the excretion of waste, thereby preventing skin aging and playing a role in beauty and skin care. Skin care is more important than other makeup, and has become a modern people's awareness of beauty care.
Repair and prevention
Light burns or sunburns caused by sun exposure, such as redness, blackening, and peeling of the skin, are mainly caused by ultraviolet rays in the sun. Sodium hyaluronate can promote the regeneration of the skin in the injured area by promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals. It also has a certain preventive effect if used in advance. Its mechanism of action is different from that of the UV absorbers commonly used in sunscreens. Therefore, the combination of HA and UV absorbers in sunscreen skin care products has a synergistic effect, which can simultaneously reduce the penetration of ultraviolet rays and repair the skin damage caused by the small amount of ultraviolet rays that penetrate, playing a dual protective role.
The combination of sodium hyaluronate, EGF and heparin can accelerate the regeneration of epidermal cells, making the skin delicate, smooth and elastic. When the skin suffers from mild burns, applying water-based cosmetics containing sodium hyaluronate on the surface can relieve pain and accelerate the healing of the skin in the injured area.
Lubrication and film-forming properties
Sodium hyaluronate is a high molecular polymer with strong lubricity and film-forming properties. Skin care products containing sodium hyaluronate have obvious lubricity and good hand feel when applied. After being applied to the skin, a thin film can be formed on the skin surface, which makes the skin smooth and moist, and protects the skin. Hair care products containing sodium hyaluronate can form a thin film on the hair surface, which plays a role in moisturizing, lubricating, protecting hair, eliminating static electricity, etc., making the hair easy to comb and flowing naturally.
Thickening property
Sodium hyaluronate has a very high viscosity in aqueous solution, and its 1% aqueous solution is gel-like. It can thicken and stabilize when added to cosmetics.
Pharmacological action
Sodium hyaluronate is a physiologically active substance widely found in animals and humans, and is distributed in human skin, synovial fluid, umbilical cord, aqueous humor and vitreous body. The molecular weight is 500,000 to 730,000 Daltons, and its solution has high viscoelasticity and contour properties. It is an auxiliary agent for ophthalmic surgery. After the liquid is injected into the anterior chamber, it maintains a certain depth of the anterior chamber of the eye, which is convenient for surgical operation, and has the functions of protecting corneal endothelial cells and intraocular tissues, reducing surgical complications, and promoting wound healing.
Sodium hyaluronate is the fourth generation of bionic cosmetic additives. It was discovered by KARL MEYER in 1934 from the vitreous body of bovine eyes. It is a macromolecular polysaccharide extracted from the vitreous body of bovine eyes. It has three characteristics: anti-aging, fresh-keeping packaging, and the use of biotechnology. Sodium hyaluronate itself is one of the components of human skin. It is the most widely distributed acidic mucosa in the human body. It exists in the matrix of connective tissue and has a good moisturizing effect.
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