Benfotiamine 99% CAS 22457-89-2 Vitamin B1 Derivatives Benfotiamine

• Customization: Available
• Certification: ISO 9001, FDA
• Product Name: Benfotiamine
• Model NO.: SENTIAN-Benfotiamine
• Grade: API
• Appearance: White Powder
• Test Method: HPLC
• Storage: Cool Dry Place
• MOQ: 1 Kg
• Sample: 5-10g Free Sample
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 99%
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 50000 Tons/Year

Product Description

Benfotiamine is an organic compound with molecular formula C19H23N4O6PS, molecular weight 466.45, chemical name: Benzoic acid-sulfur-2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamido]-1-[2-(phosphoryloxyethyl)-1-propenyl] ester, and appearance is white crystalline powder.

Product Parameters

Benfotiamine SPECIFICATION
Product name	Benfotiamine
From	Powder
CAS No.	22457-89-2
Specification	99%
Appearance	white powder
Package	1KG/Bag,5kg/bag,25kg/drum
Place of Origin	Shaan'Xi,China

 

Benfotiamine is a fat-soluble vitamin B1 derivative. In addition to its different physical and chemical properties from water-soluble vitamin B1, the structural difference is that it has an open thiazole ring, which forms physiologically active vitamin B1 through ring closure in the body.

After taking benfotiamine, the maximum blood concentration of vitamin B1 is about 5 times higher than that of ingested vitamin B1, and the maximum bioavailability is about 3.6 times that of ingested vitamin B1, and it is higher than other fat-soluble vitamin B1 derivatives. Human and animal studies have shown that benfotiamine has higher bioavailability and bioactivity than water-soluble vitamin forms. Compared with vitamin B1, benfotiamine produces higher peak and total concentrations of vitamin B1 and its phosphate in plasma, whole blood, red blood cells and tissues, and its plasma half-life is also longer. The relative bioavailability increases more significantly in muscle tissue (5 times) and brain (25 times), and in other tissues such as liver and kidney, there is also a 10~40% increase.

Adults took benfotiamine and thiamine hydrochloride orally, and the total vitamin B1 level in the blood, the increase in coenzyme vitamin B1 (thiamine pyrophosphate) and free vitamin B1 in the blood were measured. The results showed that compared with thiamine hydrochloride, benfotiamine was most highly absorbed in the digestive tract, the total vitamin B1 in the blood was maintained at a very high concentration, and the conversion rate of coenzyme vitamin B1 was also very high.

Benfotiamine is a fat-soluble derivative of vitamin B1. It improves the low bioavailability of water-soluble vitamin B1 and increases the concentration of thiamine in the blood and tissues, thereby improving the efficacy.
Benfotiamine has been widely marketed in the United States, Japan, Europe and other parts of the world. Its marketed dosage forms include tablets, granules and other dosage forms. The indications are:
(1) For the prevention and treatment of vitamin B1 deficiency;
(2) For the supplementation of vitamin B1 when the demand for vitamin B1 increases and the intake from food is insufficient (fatigue, hyperthyroidism, pregnancy, lactation, strenuous physical labor, etc.);
(3) For the treatment of non-alcoholic Wernicke's encephalopathy;
(4) For the treatment of beriberi;
(5) For the treatment of the following diseases that are presumed to be related to vitamin B1 deficiency and metabolic disorders, such as: neuralgia; muscle pain, joint pain; peripheral neuritis, peripheral nerve paralysis; myocardial metabolic disorders; constipation and other gastrointestinal motility disorders.

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.