| product name |
NMNH / reduced nicotinamide mononucleotide |
| Specification |
99% |
| grade |
food Grade |
| Package |
1KG/Bag,5kg/bag,25kg/drum |
| Appearance |
yellow powder |
| MOQ |
1KG |
NMNH is "reduced β-nicotinamide mononucleotide", which is the reduced form of NMN. The molecular formula of NMNH is C11H17N2O8P, molecular weight: 336.23g/mol, CAS No.: 108347-85-9, and it is an amorphous yellow powder. The latest research literature shows that NMNH increases NAD+ levels faster and at a higher concentration, which is an average of 5 times that of NMN. NMNH has been industrialized with a purity of ≥99% and is available in two forms: free acid and sodium salt.
Product Applications
1. NAD+ replenishment: NMNH can boost NAD+ levels, which decline with age. NAD+ is crucial for various cellular functions, including DNA repair and energy production.
2. Energy production: NAD+ is essential for the production of ATP, the cell's energy currency. NMNH supplementation may improve energy levels and metabolism.
3. Cognitive function: NMNH may support cognitive function by protecting neurons and promoting synaptic plasticity.
Neurodegenerative diseases: Preliminary research indicates that NMNH could have potential benefits for neurodegenerative diseases like Alzheimer's and Parkinson's.
1. nmnh can quickly increase NAD+ in vitro
In in vitro experiments, researchers used NMN and NMNH simultaneously to detect their ability to increase NAD+ levels in cells. Different concentrations of NMN and NMNH were added to AML12 mouse liver cells, and it was found that compared with NMN, NMNH not only significantly increased the level of NAD+ in the cells, but also accelerated the rate of increase in NAD+ concentration.
2. NMNH acts as a potent NAD+ enhancer in vitro.
To further demonstrate that NMNH can serve as an efficient NAD+ precursor, the researchers added the same concentration of NMNH to different mouse cells (AML12 and T37i) and human cells (HepG2, fibroblasts, SY5Y, and human cervical cancer cells). NMN and NMNH.
The experimental results showed that adding NMNH can increase the NAD+ content in these cells and is more effective than NMN at the same concentration.
3.nmnh can increase the concentration of NAD+ in the body
To evaluate the effects of NMNH and NMN in vivo, C57BL/6N mice were injected with vehicle (PBS) or 250 mg/kg of NMN/NMNH, and blood was collected at 1, 4, and 20 hours. Tissues were harvested 24 hours later.
The results showed that NMNH can effectively increase the concentration of NAD+ in the blood, and can quickly increase the NAD+ level within 1 hour after supplementation, which is much higher than NMN. It is worth noting that the NAD+ content in the blood dropped to the basal level 4 hours after NMN supplementation, but NMNH could maintain an NAD+ concentration that increased by more than 2 times within 20 hours after the first injection.
The researchers also found that NMNH increased NAD+ levels in multiple tissues compared to NMN, with the greatest effects in the liver (5-fold increase) and kidney (2-fold increase). Surprisingly, NMNH also significantly increased the NAD+ content in the brain, gastrocnemius muscle, brown adipose tissue, and heart, which NMN could not do.
4. nmnh can repair tubular epithelial cells
NAD+ homeostasis is essential for repairing damaged epithelial cells and maintaining cell biological activity. The researchers specifically observed whether NMNH could protect tubular epithelial cells from hypoxia/reoxygenation damage by enhancing repair.
Under normoxic conditions, supplementing with the same concentrations of NMNH and NMN can increase the concentration of NAD+ by 5 times and 2 times, respectively; under hypoxic/reoxygenated conditions, NMNH and NMN can increase the concentration of NAD+ to a higher level.
After analysis, NMNH supplementation can reduce cellular damage in hypoxia/reoxygenation injury and enhance cellular repair capacity by targeting NAD+ regeneration, enhancing mitochondrial activity and nucleotide metabolism.
| Items |
Requirements |
Results |
| |
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| Physical & Chemical |
|
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| Appearance |
yellow powder |
Conform |
| Odor |
Characteristic |
Characteristic |
| Particle Size |
98% pass 80mesh |
Complies |
| Loss on Drying |
≤5.0% |
3.65% |
| Ash |
≤5.0% |
1.96% |
| Solvent Residue |
Meet USP standard |
Complies |
| Pesticide Residue |
Meet USP standard |
Complies |
| |
|
|
| Heavy Metal |
|
|
| Lead (Pb) |
≤2.0ppm |
Conform |
| (As) |
≤1.0ppm |
Conform |
| (Cd) |
≤1.0ppm |
Conform |
| (Hg) |
≤0.1ppm |
Conform |
| |
|
|
| Microorganism |
|
|
| Total Plate Count |
≤1000cfu/g |
Conform |
| Yeasts and Molds |
≤100cfu/g |
Conform |
| Saimonella |
Negative/25g |
Conform |
| E.coli |
Negative |
Conform |
| |
|
|
| |
|
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| Assay |
98% |
98.5% |
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