| Customization: | Available |
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| Certification: | ISO, FDA, HACCP |
| Assay Method: | HPLC |
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Madecassoside is a major bioactive saponin compound derived from the herb Centella asiatica (L.) Urb., which is commonly found in tropical and subtropical regions of Asia. It is one of the primary triterpenoid constituents of this traditional medicinal plant, known for its various biological activities and therapeutic potentials.
Madecassoside has been reported to possess anti-inflammatory, antioxidant, neuroprotective, and cardioprotective effects. It has been used in traditional medicine for the treatment of conditions such as traumatic injuries, keloids, and scars. The compound has also shown promise in wound healing, with studies suggesting it can promote skin angiogenesis and collagen synthesis, as well as exhibit antifibrotic properties.
Pharmacokinetic studies have shown that madecassoside is widely distributed in the heart, liver, spleen, lungs, and kidneys of rats after oral administration. It is excreted primarily through bile, urine, and feces, with the majority of the compound being eliminated in the feces as metabolites. The compound has been found to interact with hepatobiliary efflux transporters, suggesting that P-glycoprotein and multidrug resistance-associated protein contribute to its hepatobiliary elimination.
Madecassoside has a molecular formula of C48H78O20 and a molecular weight of 955.14 g/mol. It is known to have a significant impact on the production of pro-inflammatory cytokines and has been shown to inhibit the nuclear translocation of NF-κB in Propionibacterium acnes-stimulated THP-1 human monocytic cells. Additionally, it has been demonstrated to enhance skin hydration by increasing the expression of aquaporin-3, loricrin, and involucrin in HaCaT keratinocytes, as well as promoting hyaluronan secretion in human dermal fibroblasts.
| Items | Requirements | Results |
| Physical & Chemical | ||
| Appearance | White powder | Conform |
| Odor | Characteristic | Characteristic |
| Particle Size | 98% pass 80mesh | Complies |
| Loss on Drying | ≤5.0% | 3.65% |
| Ash | ≤5.0% | 1.96% |
| Solvent Residue | Meet USP standard | Complies |
| Pesticide Residue | Meet USP standard | Complies |
| Heavy Metal | ||
| Lead (Pb) | ≤2.0ppm | Conform |
| Microorganism | ||
| Total Plate Count | ≤1000cfu/g | Conform |
| Yeasts and Molds | ≤100cfu/g | Conform |
| Saimonella | Negative/25g | Conform |
| E.coli | Negative | Conform |
| Assay | 99% | 99.5% |
Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.
Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short
Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.
Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.
Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.
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