Hypericin Natural Hypericum Perforatum / St John′s Wort Extract Hypericin

• Customization: Available
• Certification: ISO, FDA, HACCP, Halal
• Assay Method: HPLC
• Model NO.: SENTIAN-Hypericin
• Product Name: Hypericin
• Test Method: HPLC
• Storage: Cool Dry Place
• MOQ: 1kg
• Sample: 10g
• Transport: 1kg/Bag, 25kg/Drum
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 0.12%-0.3%
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 50000tons/Year

Product Description

  

 

Product Parameters

Hypericin SPECIFICATION
Product name	Hypericin
From	Powder
CAS No.	482-36-0
Specification	0.12%-0.3%
Appearance	brown powder
Package	1KG/Bag,5kg/bag,25kg/drum
Place of Origin	Shaan'Xi,China

 

Hyperoside, also known as quercetin-3-O-β-D-pyranogalactoside. It belongs to the flavonol glycosides and is an organic compound with the chemical formula C21H20O12. It is easily soluble in ethanol, methanol, acetone and pyridine and is stable under normal conditions. The aglycone is quercetin and the glycosyl is pyranogalactose, which is connected to the glycosyl by a β-glycosidic bond through the 3rd O atom of quercetin. Hyperoside is widely distributed and has multiple physiological activities such as anti-inflammatory, antispasmodic, diuretic, antitussive, antihypertensive, cholesterol-lowering, protein assimilation, local and central analgesic, and protective effects on the heart and brain blood vessels. It is an important natural product.

1. Hyperoside has a significant local analgesic effect, which is weaker than  and stronger than aspirin, and has no dependence. It is a new type of local analgesic. At the same time,
2. Hyperoside shows good protective effects on myocardial ischemia-reperfusion, cerebral ischemia-reperfusion, and cerebral infarction.
3. Hyperoside has a significant anti-inflammatory effect: after rats were implanted with wool balls, 20 mg/Kg was injected intraperitoneally every day for 7 days, which significantly inhibited the inflammatory process.
4. It has a strong antitussive effect.
5. Assimilation effect.
6. It has a strong inhibitory effect on ocular aldose reductase, which may be beneficial for preventing diabetic cataracts.

Protective effect on myocardial ischemia
Hyperoside can reduce the apoptosis rate of myocardial cells caused by hypoxia-reoxygenation, inhibit the release of lactate dehydrogenase, increase the activity of myocardial superoxide dismutase (SOD) in rats with myocardial ischemia-reperfusion injury, reduce the production of malondialdehyde (MDA), inhibit the increase of myocardial phosphokinase (CPK) in serum, reduce the formation of oxygen free radicals and nitric oxide free radicals, thereby protecting the myocardium and alleviating myocardial cell damage and apoptosis caused by ischemia-reperfusion.

Protective effect on cerebral ischemia
Hyperoside can effectively inhibit the decrease in formazan content in brain slices after hypoxia-glucose-reperfusion injury, increase the number of surviving neurons in the cortex and striatum of the ischemic brain slices, and make the neuronal cell morphology intact and well distributed. Inhibit the decrease in neuronal activity induced by hypoxia-glucose-reperfusion injury. Inhibit the decrease in the activity of SOD, LDH and glutathione peroxidase (GSHPx). Its mechanism of action may be related to free radical scavenging, inhibition of Ca2 influx and anti-lipid peroxide formation.

Protective effect on liver and gastric mucosa
Hyperoside has a significant protective effect on liver tissue and gastric mucosa. Its mechanism of action is related to antioxidant effect and promoting the restoration of NO level to normal and increasing SOD activity.

Antispasmodic and analgesic effect
Studies have found that the analgesic effect of hyperoside is produced by reducing Ca2 in pain nerve endings. At the same time, it was found that hyperoside can inhibit high potassium-induced Ca2 influx, indicating that hyperoside also has a blocking effect on nerve tissue Ca channels, and further proposed that hyperoside may be a Ca2 channel blocker. Clinical observations show that the efficacy of hyperoside injection in the treatment of primary dysmenorrhea is similar to that of atropine. Except for a few drowsiness side effects, it does not have the common adverse reactions of atropine such as tachycardia, mydriasis and burning sensation. It is an ideal antispasmodic and analgesic.

Hypolipidemic effect
Hyperoside can significantly reduce serum Tc and increase the HDL/TC ratio in hyperlipidemia mice, indicating that it has the effect of lowering cholesterol and regulating blood lipids, and has the effect of increasing HDL and mouse serum SOD activity. This effect can significantly reduce the damage of superoxide free radicals to the vascular endothelium in hyperlipidemia, and is beneficial to the decomposition and metabolism of peroxidized lipids to protect the vascular endothelium.

Enhance immune function
Hyperoside can significantly inhibit the thymus index and spleen T and B lymphocyte proliferation and peritoneal macrophage phagocytosis of mice at a dose of 300 mg/kg and 150 mg/kg in vivo; at 59 mg/kg, it significantly enhances the proliferation of spleen T and B lymphocytes and the phagocytosis of peritoneal macrophages in mice. Hyperoside can significantly promote the proliferation of spleen T and B lymphocytes and enhance the ability of T lymphocytes to produce IL-2 at an in vitro dose of 50-6.25 ml, and has a significant dose-effect relationship; hyperoside at 6.25 g/ml has a significant effect on the ability of mouse peritoneal macrophages to phagocytose neutrophils, and at 12.5-3.12 μg/ml, it has a significant effect on the ability of mouse peritoneal macrophages to release NO.

Antidepressant effect
Hypothalamus-pituitary-adrenal (HPA) activation is a common biological change in patients with severe depression, manifested as excessive secretion of adrenocorticotropic hormone and cortisol. Hyperoside can regulate the function of the HPA axis, reduce the levels of  and corticosterone, and thus play an antidepressant role.

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.