Prograf Pharmaceutical Grade 99% CAS 109581-93-3 Tacrolimus for Anti-Rejection

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: ST- Tacrolimus
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Product Name: Tacrolimus
• Grade: Food Grade
• Appearance: White Powder
• Test Method: HPLC
• Storage: Cool Dry Place
• MOQ: 1 Kg
• Sample: Free Sample
• Extraction Type: Solvent Extraction
• CAS: 109581-93-3
• Formula: C44h71no13
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 99% Tacrolimus
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 50000tons/Year

Product Description

Description

 

Tacrolimus 

 

Tacrolimus is a macrolide antibiotic with potent immunosuppressive effects, widely used in preventing organ transplant rejection and treating autoimmune diseases. It works by inhibiting calcineurin phosphatase, suppressing T-cell activation and cytokine production. Compared to cyclosporine, tacrolimus offers stronger immunosuppressive effects with fewer side effects.

   

Aspect	Details
Product Name	Tacrolimus
CAS Number	104987-11-3
MF	C44H69NO12
Molecular Weight	804.05
Grade	API
Purity	99%
Test Method	HPLC

Application & Funtion

 

FUNTION

 

1.Tacrolimus is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
2.Tacrolimus is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.
Application
1.The mechanism of action of tacrolimus in atopic dermatitis is not known.  the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12.
2.A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines.
3.Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

COA

 

Items	Requirements	Results
Physical & Chemical
Appearance	White powder	Conform
Odor	Characteristic	Characteristic
Particle Size	98% pass 80mesh	Complies
Loss on Drying	≤5.0%	3.65%
Ash	≤5.0%	1.96%
Solvent Residue	Meet USP standard	Complies
Pesticide Residue	Meet USP standard	Complies
Heavy Metal
Lead (Pb)	≤2.0ppm	Conform
Microorganism
Total Plate Count	≤1000cfu/g	Conform
Yeasts and Molds	≤100cfu/g	Conform
Saimonella	Negative/25g	Conform
E.coli	Negative	Conform
Assay	99%	99.5%

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.