Chlorogenic acid has a wide range of antibacterial effects, but can be inactivated by protein in the body. Similar to caffeic acid, it can increase the central excitability of rats when taken orally or injected intraperitoneally. It can increase the peristalsis of the small intestine of rats and mice and the tension of the rat uterus. It has a choleretic effect and can enhance the bile secretion of rats. It is sensitizing to humans. After inhaling plant dust containing this product, asthma, dermatitis, etc. may occur.
chlorogenic acid SPECIFICATION |
Product name
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chlorogenic acid
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From
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Powder
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CAS No.
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327-97-9
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Specification
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98%
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Appearance
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white powder
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Package
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1KG/Bag,5kg/bag,25kg/drum
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Place of Origin
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Shaan'Xi,China
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Chlorogenic acid is an organic compound with the chemical formula C16H18O9. It is one of the main antibacterial and antiviral effective pharmacological components of honeysuckle. The hemihydrate is a needle-shaped crystal (water). It becomes an anhydrous compound at 110ºC. The solubility in water at 25ºC is 4%, and the solubility is greater in hot water. It is easily soluble in ethanol and acetone, and very slightly soluble in ethyl acetate.
Chlorogenic acid has a wide range of biological activities. Modern scientific research on the biological activity of chlorogenic acid has penetrated into many fields such as food, health care, medicine and daily chemical industry. Chlorogenic acid is an important bioactive substance with antibacterial, antiviral, white blood cell increase, liver protection and bile duct protection, anti-tumor, blood pressure lowering, blood lipid lowering, free radical scavenging and central nervous system excitation.
Antibacterial and antiviral
Chlorogenic acid in Eucommia ulmoides has strong antibacterial and anti-inflammatory effects, aucubin and its polymers have obvious antibacterial effects, and aucubin aglycone has inhibitory effects on both Gram-negative and Gram-positive bacteria. Aucubin has antibacterial and diuretic effects and can promote wound healing; aucubin will also produce obvious antiviral effects after pre-culture with glucoside, but it does not have antiviral function itself. The Institute of Medical Science, Aichi Medical University, Japan, has confirmed through research that the alkaline substances extracted from Eucommia ulmoides have the function of resisting viruses that damage the human immune system, and this substance may be used to prevent and treat AIDS.
Antioxidant effect
Chlorogenic acid is an effective phenolic antioxidant, and its antioxidant capacity is stronger than that of caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butylated hydroxyanisole (BHA) and tocopherol. The reason why chlorogenic acid has an antioxidant effect is that it contains a certain amount of R-OH groups, which can form hydrogen free radicals with antioxidant effects to eliminate the activity of free radicals such as hydroxyl free radicals and superoxide anions, thereby protecting tissues from oxidative damage.
Free radical scavenging, anti-aging, anti-musculoskeletal aging
Chlorogenic acid and its derivatives have a stronger free radical scavenging effect than ascorbic acid, caffeic acid and tocopherol (vitamin E), and can effectively scavenge DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals, and can also inhibit the oxidation of low-density lipoprotein. Chlorogenic acid plays an important role in effectively scavenging free radicals in the body, maintaining the normal structure and function of body cells, and preventing and delaying the occurrence of tumor mutations and aging. Eucommia chlorogenic acid contains a special component that can promote the synthesis and decomposition of collagen in human skin, bones, and muscles. It has the function of promoting metabolism and preventing decline. It can be used to prevent bone and muscle decline caused by weightlessness in space for astronauts. At the same time, it was found that Eucommia chlorogenic acid has obvious anti-free radical effects both in vivo and in vitro.
Inhibit mutation and anti-tumor
Modern pharmacological experiments have proved that Eucommia chlorogenic acid has anti-cancer and anti-cancer effects. Japanese scholars have studied the antimutagenicity of Eucommia chlorogenic acid and found that this effect is related to antimutagenic components such as chlorogenic acid, revealing the importance of chlorogenic acid in tumor prevention.
Polyphenols in vegetables and fruits, such as chlorogenic acid and caffeic acid, can inhibit the mutagenicity of carcinogens aflatoxin B1 and benzo[a]-pyrene by inhibiting activating enzymes; chlorogenic acid can also achieve anti-cancer and anti-cancer effects by reducing the utilization rate of carcinogens and their transportation in the liver. Chlorogenic acid has a significant inhibitory effect on colorectal cancer, liver cancer and laryngeal cancer, and is considered to be an effective chemical protective agent for cancer.
Protective effect on cardiovascular system
Chlorogenic acid, as a free radical scavenger and antioxidant, has been proven by a large number of experiments. This biological activity of chlorogenic acid can have a protective effect on the cardiovascular system. Isochlorogenic acid B has a strong promoting effect on the release of prostaglandin (PGI2) and anti-platelet aggregation in rats; the inhibition rate of antibody-induced SRS-A release induced by guinea pig lung fragments is 62.3%. Isochlorogenic acid C also has the effect of promoting the release of PGI2. In addition, isochlorogenic acid B has a strong inhibitory effect on the biosynthesis of platelet thromboxane and endothelin damage induced by hydrogen peroxide.





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