What is lithium orotate?
Lithium orotate is an emerging form of lithium supplementation that combines orotic acid (an organic acid naturally found in dairy products) and lithium (a trace element).
Lithium has long been used as a treatment for bipolar disorder, but lithium orotate has been studied as an over-the-counter supplement with a lower lithium content, designed to support mood stability, cognitive function, and overall mental health.
Unlike traditional lithium carbonate or lithium citrate, lithium orotate is more efficiently absorbed and may have fewer side effects, making it an emerging option for people concerned about mental health and neuroprotection.
Lithium orotate SPECIFICATION |
Product name
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Lithium orotate
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From
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Powder
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CAS No.
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5266-20-6
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Specification
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99%
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Appearance
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white powder
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Package
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1KG/Bag,5kg/bag,25kg/drum
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Place of Origin
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Shaan'Xi,China
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Discovery and Research of Lithium Orotate
The concept of lithium orotate stems from the remarkable role of lithium in mood regulation.
In the mid-20th century, lithium salts were found to be effective in treating bipolar disorder, but their high doses were often associated with serious side effects.
In recent years, scientists have begun to study the possibility of providing lithium in a lower dose form and have discovered that orotate can serve as a stable carrier for lithium, helping to reduce the potential toxicity of traditional lithium salts while retaining their benefits.
Effects of lithium orotate
1. Mood stability
Lithium orotate has the potential to improve mild to moderate mood swings, especially in cases of anxiety and mild depression.
2. Neuroprotection
Lithium has been shown to promote the secretion of brain nerve, which helps repair and protect nerve cells, laying the foundation for the study of lithium orotate in alleviating neurodegenerative diseases such as Alzheimer's disease.
3. Anti-inflammatory and antioxidant
Some studies have shown that lithium may have a positive effect on overall health by reducing inflammatory factors and oxidative stress.
4. Cognitive function
Preliminary studies have shown that lithium orotate may enhance cognitive function and improve attention and memory.
Recommended use of lithium orotate
When using lithium orotate, the dose should be adjusted according to individual needs. Here is a general reference:
Generally recommended dose for adults
5-20 mg of elemental lithium per day (usually corresponding to 50-100 mg of lithium orotate).
Emotional regulation (mild anxiety/depression)
The recommended starting dose is 10 mg of elemental lithium/day, which can be gradually adjusted according to the response.
Neuroprotection or cognitive support
10-15 mg of elemental lithium per day, long-term use requires regular monitoring.
Special populations
Elderly: Lower doses (such as 5 mg of elemental lithium/day) are recommended because of their low metabolic capacity.
Pregnant and lactating women: Avoid use because safety has not been fully studied.
Consumption and use precautions
Choose a regular brand
Lithium orotate is still an emerging product, and brands that have passed third-party testing should be selected to ensure that the lithium content and purity meet the standards.
Pay attention to the dose
Do not exceed the recommended dose to avoid the risk of lithium overdose.
Monitor health
Long-term users are advised to test blood lithium concentrations and renal function every 6-12 months.
Avoid using with alcohol
Alcohol may increase the side effects of lithium, such as drowsiness and slowed reaction time.
Consult a doctor
If you have kidney disease, heart disease, or are taking other medications, you must consult a doctor before using lithium orotate.





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