China Supply 99% CAS 108963-96-8 Boc-L-Pyroglutamic Acid Methyl Ester

• Customization: Available
• CAS No.: 108963-96-8
• Formula: C11h17no5
• Model NO.: SENTIAN-Boc-L-Pyroglutamic acid methyl ester
• EINECS: 600-890-6
• Type: Synthesis Material Intermediates
• Appearance: Powder
• Quality: Refined
• Colour: White
• Product Name: Boc-L-Pyroglutamic Acid Methyl Ester
• Appearence: White Powder
• Sample: 5-10g
• MOQ: 1kg
• Storage: Cool Dry Place
• Package: Drum, Vacuum Packed
• Express Time: 5-7 Days
• Shipping Method: by Express, Air or Sea, Provide The Most Cost-Effe
• Payment Method: Credit Card, T/T, Paypal, Western Union and Other
• Transport Package: Drum, Aluminum Foil Bag
• Specification: 99%
• Trademark: SENTIAN
• Origin: Shanxi, China
• Production Capacity: 500kg/Month

Product Description

Describtion

 

Boc-L-Pyroglutamic Acid Methyl Ester is a protected derivative of L-pyroglutamic acid (5-oxoproline), featuring a Boc (tert-butoxycarbonyl) group on the nitrogen and a methyl ester on the carboxyl group. It is a versatile chiral building block widely used in peptide synthesis, medicinal chemistry, and drug discovery, particularly for cyclic peptide and peptidomimetic applications.

Acetaminophen SPECIFICATION
Product name	Boc-L-Pyroglutamic acid methyl ester
Appearance	White powder
Specification	99%
Package	1KG/Bag,5kg/bag,25kg/drum
Place of Origin	Shaan'Xi,China

Application & Funtion

 

Key Features & Benefits:

Dual Protection - The Boc group shields the amino group, while the methyl ester protects the carboxyl group, enabling selective deprotection and further modifications.
Chiral Purity - High enantiomeric purity (>98%) ensures reliable performance in asymmetric synthesis.
Cyclic Structure - The pyroglutamic acid (5-oxoproline) scaffold is valuable for designing constrained peptides and bioactive molecules.
Compatibility - Suitable for Boc- and Fmoc-based solid-phase peptide synthesis (SPPS).

Applications & Uses:

Peptide Synthesis - Used as a cyclic amino acid precursor in the synthesis of modified peptides, particularly those with N-terminal pyroglutamate (pGlu) motifs (common in hormones like TRH and neuropeptides).

Drug Discovery - Key intermediate for peptidomimetics, protease inhibitors, and GPCR-targeting compounds.

Constrained Peptides - The rigid pyroglutamate ring helps stabilize peptide conformations, improving metabolic stability and receptor binding.

Bioconjugation - Methyl ester can be hydrolyzed for further coupling reactions in linker chemistry (e.g., ADC development).

 

Company

FAQ

Q1. What's the MOQ?
A: MOQ is the minimum sales quantity of the product. Because each product has different prices and different packaging methods, there will be differences. Please consult the relevant professional sales manager for details.

Q2. What's the shipping time?
A: Usually the products we sell have enough stock to deliver the goods in a short

Q3.What transportation methods does our company have?
A: Our company cooperates with DHL and FedEx, as well as airlines and shipping companies. There are also some more efficient transportation methods, such as dedicated transportation lines.

Q4. Can you supply the free sample?
A: Generally, we will provide samples for customer testing to ensure that the quality of our products meets customer requirements.

Q5.Does our company support third-party testing?
A: Our company has long-term cooperation with well-known third-party testing agencies and can provide third-party testing services.